Amyloidosis Staging

Cardiac

Marker/Thresholds:  

• NT-proBNP > 332 ng/L
• cTnT > 0.035 ng/mL

Stages:

• I. no markers above cutoffs
• II. one marker above cutoffs
• IIIa. both markers above cutoffs and NT-proBNP < 8500 ng/L
• IIIb. both markers above cutoffs and NT-proBNP 8500 ng/L or higher

Revised Mayo

Marker/Thresholds:

• NT-proBNP > 1800 ng/L
• cTnT >0.025 ng/mL
• dFLC > 180 mg/L

Stages: 

• I. 0 markers above cutoffs
• II. 1 marker above cutoffs
• III. 2 markers above cutoffs
• IV. 3 markers above cutoffs

Renal

Marker/Thresholds:

• eGFR < 50 mL/min/1.73m^2
• Proteinuria > 5g/24h

Stages:

• I. both eGFR above and proteinuria below cutoffs
• II. either eGFR below or proteinuria above cutoffs
• III. both eGFR below and proteinuria above cutoffs